2-[1,1'-Biphenyl]-4-yl-5-methyl-4-oxazoleethanol

Base Information

Chemical Name:2-[1,1'-Biphenyl]-4-yl-5-methyl-4-oxazoleethanol
CAS No.:328918-85-0
Molecular Formula:C₁₈H₁₇NO₂
Molecular Weight:279.338
Hs Code.:
DSSTox Substance ID:DTXSID001238733

Synonyms:2-[1,1'-Biphenyl]-4-yl-5-methyl-4-oxazoleethanol;SCHEMBL4888378;DTXSID001238733;328918-85-0

Suppliers and Price of 2-[1,1'-Biphenyl]-4-yl-5-methyl-4-oxazoleethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[1,1'-Biphenyl]-4-yl-5-methyl-4-oxazoleethanol

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:279.125928785
Heavy Atom Count:21
Complexity:308

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(N=C(O1)C2=CC=C(C=C2)C3=CC=CC=C3)CCO

Technology Process of 2-[1,1'-Biphenyl]-4-yl-5-methyl-4-oxazoleethanol

There total 8 articles about 2-[1,1'-Biphenyl]-4-yl-5-methyl-4-oxazoleethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 328918-84-9
2-(4-bromophenyl)-5-methyl-4-oxazoleethanol

: 98-80-6
phenylboronic acid

: 328918-85-0
2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethanol

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In propan-1-ol; water; for 1.5h; Heating;
DOI:10.1021/jm0155188

Reference yield:

: 328918-80-5
4,5-dimethyl-2-(4-bromophenyl)-oxazole oxide

: 328918-85-0
2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / POCl₃ / CHCl₃

2: 100 percent / KI / dimethylformamide

3: 60 percent / KOH / 2-methoxy-ethanol

4: 72 percent / BH₃ / tetrahydrofuran; methanol

5: 95 percent / Pd(OAc)2; PPh₃

With palladium diacetate; potassium hydroxide; borane; triphenylphosphine; potassium iodide; trichlorophosphate; In tetrahydrofuran; methanol; chloroform; 2-methoxy-ethanol; N,N-dimethyl-formamide; 5: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.09.031

Reference yield:

: 328918-81-6
2-(4-bromophenyl)-4-(chloromethyl)-5-methyl-1,3-oxazole

: 328918-85-0
2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / KI / dimethylformamide

2: 60 percent / KOH / 2-methoxy-ethanol

3: 72 percent / BH₃ / tetrahydrofuran; methanol

4: 95 percent / Pd(OAc)2; PPh₃

With palladium diacetate; potassium hydroxide; borane; triphenylphosphine; potassium iodide; In tetrahydrofuran; methanol; 2-methoxy-ethanol; N,N-dimethyl-formamide; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.09.031