(1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

Base Information

Chemical Name:(1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol
CAS No.:577978-30-4
Molecular Formula:C₄₇H₅₀N₄O₇
Molecular Weight:782.937
Hs Code.:

(1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

Synonyms:(1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

Suppliers and Price of (1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

There total 5 articles about (1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 106-95-6
allyl bromide

: 402477-42-3
(2S,3S,4R,5R)-tert-butyl 2-(5-((benzyloxy)methyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-((trityloxy)methyl)pyrrolidine-1-carboxylate

: 577978-29-1
(1S)-2-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

: 577978-30-4
(1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

Guidance literature:: (2S,3S,4R,5R)-tert-butyl 2-(5-((benzyloxy)methyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-((trityloxy)methyl)pyrrolidine-1-carboxylate; With di(n-butyl)tin oxide; In toluene; for 1h; Heating;

allyl bromide; With tetrabutylammomium bromide; In toluene; for 4h; Heating;
DOI:10.1021/jm030145r

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 577978-30-4
(1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2.28 g / Et₃N / methanol / 1 h

2.1: 88 percent / N,N-diisopropylethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

3.1: dibutyltin oxide / toluene / 1 h / Heating

3.2: 30 percent / Bu₄NBr / toluene / 4 h / Heating

With dmap; di(n-butyl)tin oxide; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/jm030145r

Reference yield:

: 364046-18-4
1S-5-O-tert-butyldimethylsilyl-1,4-dideoxy-1-C-[(4-methyoxypyrrolo[3,2-d]pyrimidin-9-N-(benzyloxomethyl)-7-yl)]-1,4-imino-2,3-O-isopropylidine-D-ribitol

: 577978-30-4
(1S)-3-O-allyl-1-(7-N-benzyloxymethyl-9-deaza-6-O-methylhypoxanthin-9-yl)-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-5-O-triphenylmethyl-D-ribitol

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. TFA / tetrahydrofuran / 1.5 h / Heating

2.1: 2.28 g / Et₃N / methanol / 1 h

3.1: 88 percent / N,N-diisopropylethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

4.1: dibutyltin oxide / toluene / 1 h / Heating

4.2: 30 percent / Bu₄NBr / toluene / 4 h / Heating

With dmap; di(n-butyl)tin oxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm030145r