tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate

Base Information

• Chemical Name: tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate
• CAS No.: 182874-95-9
• Molecular Formula: C₁₈H₁₈F₂O₃
• Molecular Weight: 320.336
• Mol file: 182874-95-9.mol

Synonyms:tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate

Chemical Property of tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate

There total 1 articles about tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2,4,5-trifluorobenzoate (182875-05-4) + benzyl alcohol (100-51-6,185532-71-2) → tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate (182874-95-9) + 2-Benzyloxy-4,5-difluoro-benzoic acid tert-butyl ester

Guidance literature:

With potassium tert-butylate; Yield given. Yields of byproduct given; 1.) THF, 5 deg C, 0.5 h, 2.) THF, -65 deg C, 3 h and room t.;

DOI:10.1016/0040-4039(96)01425-6

Reference yield: 70.0%

piperidine (110-89-4) + tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate (182874-95-9) → 4-Benzyloxy-5-fluoro-2-piperidin-1-yl-benzoic acid tert-butyl ester

Guidance literature:

In tetrahydrofuran; at 65 ℃;

DOI:10.1016/0040-4039(96)01425-6

Reference yield:

tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate (182874-95-9) → tert-butyl 2,5-difluoro-4-hydroxybenzoate (1252900-77-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 5h;

upstream raw materials:

tert-butyl 2,4,5-trifluorobenzoate

benzyl alcohol

Downstream raw materials:

tert-butyl 2,5-difluoro-4-hydroxybenzoate