sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

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Chemical Name:sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate
CAS No.:1620085-47-3
Molecular Formula:C₂₁H₁₄FN₈O₂S*Na
Molecular Weight:484.449
Hs Code.:

Synonyms:sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

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Chemical Property of sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

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Technology Process of sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

There total 4 articles about sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1620085-46-2
ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

: 1620085-47-3
sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃;
DOI:10.1016/j.bmcl.2014.05.080

Reference yield:

: 1214264-40-0
2-amino-4-((trimethylsilyl)ethynyl)pyrimidine

: 1620085-47-3
sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3: sodium L-ascorbate; copper(II) sulfate penta hydrate / water; tert-butyl alcohol / 0.33 h / 100 °C / Microwave irradiation

4: sodium hydroxide / ethanol; water / 20 °C

With copper(II) sulfate penta hydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; sodium hydroxide; In tetrahydrofuran; ethanol; water; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2014.05.080

Reference yield:

: 1620085-45-1
7-ethynyl-2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidine

: 1620085-47-3
sodium 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium L-ascorbate; copper(II) sulfate penta hydrate / water; tert-butyl alcohol / 0.33 h / 100 °C / Microwave irradiation

2: sodium hydroxide / ethanol; water / 20 °C

With copper(II) sulfate penta hydrate; sodium L-ascorbate; sodium hydroxide; In ethanol; water; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2014.05.080