ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Base Information

Chemical Name:ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate
CAS No.:1620085-46-2
Molecular Formula:C₂₃H₁₉FN₈O₂S
Molecular Weight:490.521
Hs Code.:

Synonyms:ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Suppliers and Price of ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

There total 3 articles about ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 637-81-0
ethyl-2-azidoacetate

: 1620085-45-1
7-ethynyl-2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidine

: 1620085-46-2
ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: With copper(II) sulfate penta hydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 100 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1016/j.bmcl.2014.05.080

Reference yield:

: 1214264-40-0
2-amino-4-((trimethylsilyl)ethynyl)pyrimidine

: 1620085-46-2
ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3: sodium L-ascorbate; copper(II) sulfate penta hydrate / water; tert-butyl alcohol / 0.33 h / 100 °C / Microwave irradiation

With copper(II) sulfate penta hydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; ethanol; water; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2014.05.080

Reference yield:

: 1629992-03-5
2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)-7-((trimethylsilyl)ethynyl)imidazo[1,2-a]pyrimidine

: 1620085-46-2
ethyl 2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulfate penta hydrate / water; tert-butyl alcohol / 0.33 h / 100 °C / Microwave irradiation

With copper(II) sulfate penta hydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2014.05.080