3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one

Base Information

Chemical Name:3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one
CAS No.:1308253-19-1
Molecular Formula:C₂₃H₂₀F₃N₃O₂S
Molecular Weight:459.492
Hs Code.:

Synonyms:3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one

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Chemical Property of 3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one

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Technology Process of 3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one

There total 1 articles about 3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 37660-23-4
6-amino-2-benzylthio-3,4-dihydropyrimidin-4-one

: 1308253-17-9
3-(chloromethyl)-4-(4-trifluoromethylphenyl)-3-buten-2-one

: 1308253-19-1
3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one

Guidance literature:: With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2011.03.011

Reference yield:

: 1308253-19-1
3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one

: C₂₃H₁₈F₃N₃O₃S

Guidance literature:: Multi-step reaction with 2 steps

1: titanium(IV) chloride tetrahydrofuran / tetrahydrofuran / 72 h / Reflux; Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With titanium(IV) chloride tetrahydrofuran; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.03.011

Reference yield:

: 1308253-19-1
3-({[6-amino-2-(benzylsulfanyl)-4-pyrimidinyl]oxy}methyl)-4-[4-(trifluoromethyl)phenyl]-3-buten-2-one

: 1308253-28-2
2-anilino-7-methyl-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: titanium(IV) chloride tetrahydrofuran / tetrahydrofuran / 72 h / Reflux; Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3: 1 h / 110 °C / Microwave irradiation

With titanium(IV) chloride tetrahydrofuran; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.03.011