7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one
CAS No.:1308253-27-1
Molecular Formula:C₂₀H₁₉F₃N₄O
Molecular Weight:388.392
Hs Code.:

Synonyms:7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

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Chemical Property of 7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

There total 4 articles about 7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: C₂₃H₁₈F₃N₃O₃S

: 1308253-27-1
7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: at 110 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.tet.2011.03.011

Reference yield:

: 1308253-21-5
2-(benzylsulfanyl)-7-methyl-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

: 1308253-27-1
7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: 1 h / 110 °C / Microwave irradiation

With 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.03.011

Reference yield:

: 1308253-17-9
3-(chloromethyl)-4-(4-trifluoromethylphenyl)-3-buten-2-one

: 1308253-27-1
7-methyl-2-(1-pyrrolidinyl)-6-[4-(trifluoromethyl)benzyl]pyrido[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 20 °C

2: titanium(IV) chloride tetrahydrofuran / tetrahydrofuran / 72 h / Reflux; Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

4: 1 h / 110 °C / Microwave irradiation

With titanium(IV) chloride tetrahydrofuran; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.03.011