[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester

Base Information

• Chemical Name: [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester
• CAS No.: 334936-14-0
• Molecular Formula: C₁₅H₁₇F₆O₇P
• Molecular Weight: 454.26
• Mol file: 334936-14-0.mol

Synonyms:[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester

Chemical Property of [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester

There total 2 articles about [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,4-dimethoxylbenzyl alcohol (7314-44-5) + 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetic acid (209065-57-6) → [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester (334936-14-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 0 ℃; for 3h;

DOI:10.1016/S0040-4039(00)02116-X

Reference yield:

bis(2,2,2-trifluoroethyl)(methyl)phosphonate (757-95-9) → [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester (334936-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / LHMDS / tetrahydrofuran

2: 87 percent / DMAP; EDCI / 3 h / 0 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)02116-X

Reference yield: 80.0%

{6-[5-(tert-butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde (334936-03-7) + [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 2,4-dimethoxy-benzyl ester (334936-14-0) → (Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid 2,4-dimethoxy-benzyl ester (334936-16-2)

Guidance literature:

With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(00)02116-X

upstream raw materials:

2,4-dimethoxylbenzyl alcohol

2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetic acid

bis(2,2,2-trifluoroethyl)(methyl)phosphonate

Downstream raw materials:

(Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid 2,4-dimethoxy-benzyl ester

(Z)-4-[(2R,6R)-6-((S)-2-Methyl-5-oxo-pentyl)-5,6-dihydro-2H-pyran-2-yl]-but-2-enoic acid 2,4-dimethoxy-benzyl ester

(Z)-4-[(2R,6R)-6-((S)-5-Hydroxy-2-methyl-pentyl)-5,6-dihydro-2H-pyran-2-yl]-but-2-enoic acid 2,4-dimethoxy-benzyl ester

(Z)-4-[(2R,6R)-6-((S)-4-Formyl-2-methyl-pent-4-enyl)-5,6-dihydro-2H-pyran-2-yl]-but-2-enoic acid 2,4-dimethoxy-benzyl ester