2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester

Base Information

Chemical Name:2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester
CAS No.:155220-10-3
Molecular Formula:C₂₁H₂₂N₂O₄
Molecular Weight:366.417
Hs Code.:

Synonyms:2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester

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Chemical Property of 2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester

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Technology Process of 2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester

There total 4 articles about 2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 155219-96-8
α-acetoxy-1-(allyloxycarbonyl)-2,2-dibenzylhydrazineacetic acid methyl ester

: 155220-10-3
2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester

Guidance literature:: With tin(IV) chloride; In dichloromethane; 1.) -78 deg C, 15 min; 2.) r.t.;
DOI:10.1016/S0040-4020(01)96267-2

Reference yield:

: 100-44-7
benzyl chloride

: 155220-10-3
2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / K₂CO₃, LiI / ethanol / 18 h / Heating

2: toluene / 40 h

3: pyridine / DMAP / 18 h / Ambient temperature

4: 91 percent / SnCl₄ / CH₂Cl₂ / 1.) -78 deg C, 15 min; 2.) r.t.

With pyridine; tin(IV) chloride; potassium carbonate; lithium iodide; dmap; In ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)96267-2

Reference yield:

: 155219-85-5
1,1-dibenzyl-2-hydrazinecarboxylic acid allyl ester

: 155220-10-3
2-(allyloxycarbonyl)-3-benzyl-1,2,3,4-tetrahydro-1-phthalazinecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 40 h

2: pyridine / DMAP / 18 h / Ambient temperature

3: 91 percent / SnCl₄ / CH₂Cl₂ / 1.) -78 deg C, 15 min; 2.) r.t.

With pyridine; tin(IV) chloride; dmap; In dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)96267-2