N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide

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Chemical Name:N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide
CAS No.:1610804-89-1
Molecular Formula:C₃₇H₃₉N₅O₆
Molecular Weight:649.747
Hs Code.:

Synonyms:N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide

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Chemical Property of N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide

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Technology Process of N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide

There total 8 articles about N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

: 1610805-24-7
C₁₈H₁₇NO₄

: 1610805-19-0
2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1610804-89-1
N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In methanol; water; at 20 ℃;
DOI:10.1111/cbdd.12301

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 1610804-89-1
N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 3 h / Reflux

2: ammonium chloride; iron / ethanol / 3.5 h / Reflux

3: triethylamine / dichloromethane / 24 h / 0 - 20 °C

4: copper(II) sulfate; sodium L-ascorbate / methanol; water / 20 °C

With iron; potassium carbonate; ammonium chloride; copper(II) sulfate; sodium L-ascorbate; triethylamine; In methanol; ethanol; dichloromethane; water; acetone;
DOI:10.1111/cbdd.12301

Reference yield:

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 1610804-89-1
N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 17 h / Reflux

2.1: hydrogen; palladium on activated charcoal / ethanol; dichloromethane / 24 h / 20 °C

3.1: acetic acid; sodium nitrite / 1.33 h / -5 - 5 °C

3.2: 1 h / 0 - 5 °C

4.1: copper(II) sulfate; sodium L-ascorbate / methanol; water / 20 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; copper(II) sulfate; acetic acid; sodium L-ascorbate; sodium nitrite; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1111/cbdd.12301