C₁₆H₁₄F₃N₃

Base Information

Chemical Name:C₁₆H₁₄F₃N₃
CAS No.:1420205-99-7
Molecular Formula:C₁₆H₁₄F₃N₃
Molecular Weight:305.302
Hs Code.:

C<sub>16</sub>H<sub>14</sub>F<sub>3</sub>N<sub>3</sub>

Synonyms:C₁₆H₁₄F₃N₃

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Chemical Property of C₁₆H₁₄F₃N₃

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Technology Process of C₁₆H₁₄F₃N₃

There total 9 articles about C₁₆H₁₄F₃N₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1420205-98-6
C₁₉H₂₂F₃N₃Si

: 1420205-99-7
C₁₆H₁₄F₃N₃

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 66417-30-9
2-bromo-1-methyl-4-(trifluoromethyl)benzene

: 1420205-99-7
C₁₆H₁₄F₃N₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 150 °C / Microwave irradiation

3.1: palladium 10% on activated carbon; hydrogen / methanol; isopropyl alcohol / 50 °C / Inert atmosphere

4.1: hydrogen bromide; sodium nitrite / water / 0 - 20 °C

4.2: 0 - 20 °C

5.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; potassium acetate; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: |Suzuki Coupling / 5.1: |Sonogashira Cross-Coupling;

Reference yield:

: 1124383-00-1
N-(3-bromo-2-pyridinyl)-N’-carboethoxy-thiourea

: 1420205-99-7
C₁₆H₁₄F₃N₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 6 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 150 °C / Microwave irradiation

3.1: palladium 10% on activated carbon; hydrogen / methanol; isopropyl alcohol / 50 °C / Inert atmosphere

4.1: hydrogen bromide; sodium nitrite / water / 0 - 20 °C

4.2: 0 - 20 °C

5.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: |Suzuki Coupling / 5.1: |Sonogashira Cross-Coupling;