(4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene

Base Information

Chemical Name:(4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene
CAS No.:736948-26-8
Molecular Formula:C₁₇H₂₅NO₂S
Molecular Weight:307.457
Hs Code.:

Synonyms:(4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene

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Chemical Property of (4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene

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Technology Process of (4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene

There total 5 articles about (4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 736948-20-2
(4S,2Z)-2-bromo-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hept-2-enyl methylsulfonate

: 736948-26-8
(4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene

Guidance literature:: With diethylzinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; at 20 ℃; for 4h;
DOI:10.1021/jo049663f

Reference yield:

: (Z)-(S)-4-Amino-2-bromo-6-methyl-hept-2-enoic acid methyl ester

: 736948-26-8
(4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene

Guidance literature:: Multi-step reaction with 4 steps

1: 532 mg / Et₃N / CHCl₃ / 0.5 h / 0 °C

2: 89 percent / DIBAL-H / CH₂Cl₂; hexane / 3 h / -78 °C

3: 99 percent / Et₃N / tetrahydrofuran / 4 h / -78 - 0 °C

4: 81 percent / Et₂Zn / Pd(PPh₃)4 / tetrahydrofuran; hexane / 4 h / 20 °C

With diethylzinc; diisobutylaluminium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; chloroform;
DOI:10.1021/jo049663f

Reference yield:

: 736948-62-2
Methyl (4S,2Z)-2-bromo-4-[N-(tert-butoxycarbonyl)amino]-6-methylhept-2-enoate

: 736948-26-8
(4S)-6-methyl-4-[N-(2,4,6-trimethylphenylsulfonyl)amino]hepta-1,2-diene

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / CHCl₃ / 1.5 h / 0 °C

2: 532 mg / Et₃N / CHCl₃ / 0.5 h / 0 °C

3: 89 percent / DIBAL-H / CH₂Cl₂; hexane / 3 h / -78 °C

4: 99 percent / Et₃N / tetrahydrofuran / 4 h / -78 - 0 °C

5: 81 percent / Et₂Zn / Pd(PPh₃)4 / tetrahydrofuran; hexane / 4 h / 20 °C

With diethylzinc; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; chloroform;
DOI:10.1021/jo049663f