N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride

Base Information

Chemical Name:N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride
CAS No.:1319210-11-1
Molecular Formula:C₂₄H₃₀N₂O₂*ClH
Molecular Weight:414.975
Hs Code.:

Synonyms:N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride

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Chemical Property of N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride

Chemical Property:

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Technology Process of N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride

There total 4 articles about N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1260244-03-8
2-(4-propoxyphenyl)-4-hydroxyquinoline

: 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride

: 1319210-11-1
N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride

Guidance literature:: 2-(4-propoxyphenyl)-4-hydroxyquinoline; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-chloro-N,N-diethylethylamine hydrochloride; In N,N-dimethyl-formamide; at 110 ℃; for 5h;

With hydrogenchloride;
DOI:10.1021/jm200370y

Reference yield:

: 1319210-02-0
N-(2-acetylphenyl)-4-propoxybenzamide

: 1319210-11-1
N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate; tert-butyl alcohol / 3 h / 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 5 h / 110 °C

With potassium tert-butylate; potassium carbonate; tert-butyl alcohol; In N,N-dimethyl-formamide;
DOI:10.1021/jm200370y

Reference yield:

: 5438-19-7
4-propoxybenzoic acid

: 1319210-11-1
N,N-diethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 70 °C

2.1: potassium tert-butylate; tert-butyl alcohol / 3 h / 60 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 5 h / 110 °C

With potassium tert-butylate; potassium carbonate; triethylamine; tert-butyl alcohol; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm200370y