4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine

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Chemical Name:4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine
CAS No.:1283727-43-4
Molecular Formula:C₁₉H₂₁Cl₂N₅OS
Molecular Weight:438.381
Hs Code.:

Synonyms:4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine

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Chemical Property of 4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine

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Technology Process of 4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine

There total 3 articles about 4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1283727-42-3
1-(2-hydroxy-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

: 1283727-43-4
4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: With N,N-dimethyl-formamide; trichlorophosphate; In chloroform; for 8h; Reflux;
DOI:10.1021/jm1012819

Reference yield:

: 3240-94-6
N-(2-chlorethyl)morpholine

: 1283727-43-4
4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; N,N-dimethyl-formamide / 6 h / Reflux

2: N,N-dimethyl-formamide; trichlorophosphate / chloroform / 8 h / Reflux

With N,N-dimethyl-formamide; sodium hydroxide; trichlorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm1012819

Reference yield:

: 679805-48-2
1-(2-hydroxy-2-phenylethyl)-6-thioxo-1,5,6,7-tetrahydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

: 1283727-43-4
4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; N,N-dimethyl-formamide / 6 h / Reflux

2: N,N-dimethyl-formamide; trichlorophosphate / chloroform / 8 h / Reflux

With N,N-dimethyl-formamide; sodium hydroxide; trichlorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm1012819