679805-48-2

Upstream product

• 383911-62-4 5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 679805-47-1 ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylate 

Downstream Products

• 679805-50-6 1-(2-hydroxy-2-phenylethyl)-6-(ethylthio)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 1244677-71-1 C₁₆H₁₈N₄O₂S 
• 1283727-42-3 1-(2-hydroxy-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 933770-89-9 1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 933770-90-2 N-benzyl-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1283727-44-5 1-(2-chloro-2-phenylethyl)-N-(4-fluorobenzyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1283727-45-6 1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-N-(2-phenylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1283727-46-7 N-(3-chlorophenyl)-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1283727-47-8 1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1283727-43-4 4-chloro-1-(2-chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-1H-pyrazolo[3,4-d]pyrimidine 
• 1262793-58-7 2-(4-benzylamino-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-ethanol 

Relevant academic research and scientific papers

Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice

New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-free assay. Some of them significantly reduced the growth of human osteogenic sarcoma (SaOS-2) cells. The best compound, in terms of inhibitory properties t

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation

We report here the synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biological properties as inhibitors of isolated Src and cell line proliferation (A431 and 8701-BC cells). Such compounds block the growth of cancer cells by interfe

New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation

New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic

Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d] pyrimidines 4-amino substituted and their biological evaluation

A new series of 4-amino-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines (2a-m) bearing the 2-chloro-2-phenylethyl chain at the N1 position, has been synthesized. The affinity of these compounds for A1 adenosine receptor (A1AR) was measure

Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells

Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast cancer cells 8701-BC

4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF

4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoural agents.