5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride

Base Information

Chemical Name:5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride
CAS No.:110117-70-9
Molecular Formula:C₁₃H₁₅ClN₂OS*ClH
Molecular Weight:319.255
Hs Code.:

Synonyms:5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride

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Chemical Property of 5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride

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Technology Process of 5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride

There total 6 articles about 5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 110117-69-6
5-(hydroxymethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methylimidazole

: 110117-70-9
5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride

Guidance literature:: With thionyl chloride; 1.) 0 deg C, 30 min, 2.) RT, 30 min;
DOI:10.1248/cpb.42.1784

Reference yield:

: 110117-68-5
4-<<(4-methoxyphenyl)methyl>thio>-1-methylimidazole

: 110117-70-9
5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / NaOAc / acetic acid; H₂O / 3.5 h / Heating

2: 93 percent / thionyl chloride / 0.5 h / 25 °C

With thionyl chloride; sodium acetate; In water; acetic acid;
DOI:10.1021/jo00228a060

Reference yield:

: 6258-60-2
p-methoxybenzylmercaptan

: 110117-70-9
5-(chloromethyl)-4-<<(4-methoxyphenyl)methyl>thio>-1-methyl-1H-imidazole hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / NaH / dimethylformamide / 1 h / 110 °C

2: 100 percent / NaBH₄ / methanol / 0.5 h / Ambient temperature

3: 98 percent / SOCl₂ / 1.) 0 deg C, 30 min, 2.) RT, 30 min

With sodium tetrahydroborate; thionyl chloride; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.1784