2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester
• CAS No.: 1187560-71-9
• Molecular Formula: C₂₄H₁₉F₁₂NO₃
• Molecular Weight: 597.401
• Mol file: 1187560-71-9.mol

Synonyms:2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester

Chemical Property of 2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester

There total 1 articles about 2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3,6-bis(trifluoromethyl)bromobenzene (328-70-1) + (S)-N-(ethoxycarbonyl)proline (5700-74-3) → 2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester (1187560-71-9)

Guidance literature:

3,6-bis(trifluoromethyl)bromobenzene; With iodine; magnesium; In diethyl ether; for 2.5h; Inert atmosphere; Reflux;

(S)-N-(ethoxycarbonyl)proline; In diethyl ether; at 0 ℃; Inert atmosphere;

DOI:10.1039/b908967e

Reference yield: 96.0%

2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester (1187560-71-9) → (S)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol (848821-76-1)

Guidance literature:

With potassium hydroxide; In methanol; for 5h; Reflux;

DOI:10.1039/b908967e

upstream raw materials:

3,6-bis(trifluoromethyl)bromobenzene

(S)-N-(ethoxycarbonyl)proline

Downstream raw materials:

(S)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol