5700-74-3

Basic information

• Product Name: ETOC-PRO-OH
• Synonyms: L-PYRROLIDINE-1,2-DICARBOXYLIC ACID-1-ETHYL ESTER;ETOC-PRO-OH;N-ALPHA-ETHOXYCARBONYL-L-PROLINE;Pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester;(2S)-1-carbethoxyproline;(2S)-1-ethoxycarbonyl-2-pyrrolidinecarboxylic acid;(2S)-1-ethoxycarbonylpyrrolidine-2-carboxylic acid;1-(ethoxycarbonyl)proline
• CAS NO: 5700-74-3
• Molecular Formula: C₈H₁₃NO₄
• Molecular Weight: 187.19
• Mol File: 5700-74-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 328.5°Cat760mmHg
• Flash Point: 152.5°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 3.74E-05mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETOC-PRO-OH(CAS DataBase Reference)
• NIST Chemistry Reference: ETOC-PRO-OH(5700-74-3)
• EPA Substance Registry System: ETOC-PRO-OH(5700-74-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5700-74-3(Hazardous Substances Data)

Usage

General Description

ETOC-PRO-OH, also known as ethoxylated propoxylated propanol, is a chemical compound used primarily as a surfactant and emulsifier in various industrial and personal care products. It is a non-ionic surfactant that helps to reduce the surface tension of liquids, allowing them to spread and penetrate more easily. ETOC-PRO-OH is often used in cleaning products, detergents, and cosmetics to improve their cleaning and foaming properties. It is also known for its ability to solubilize oils and other hydrophobic substances in water-based formulations. Additionally, ETOC-PRO-OH is considered to be less toxic and biodegradable, making it a preferable option for environmentally friendly formulations.

InChI:InChI=1/C8H13NO4/c1-2-13-8(12)9-5-3-4-6(9)7(10)11/h6H,2-5H2,1H3,(H,10,11)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 147-85-3 L-proline 
• 147-85-3 L-proline 
• 74877-64-8 ethyl α-methoxyvinyl carbonate 

Downstream Products

• 360068-90-2 (S)-(-)-α,α-di(4-vinylphenyl)-2-[(N-ethoxycarbonyl)pyrrolidine]methanol 
• 1187560-71-9 2-[bis(3,5-bis(trifluoromethyl)phenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester 
• 1187560-75-3 2-[bis(4-trifluoromethylphenyl)hydroxymethyl]pyrrolidine-1-carboxylic acid ethyl ester 
• 1008530-28-6 (S)-ethyl 2-((S)-1-((R)-4-benzyl-4,5-dihydrooxazol-2-yl)-2-methylpropylcarbamoyl)pyrrolidine-1-carboxylate 
• 1238965-61-1 (S)-1-ethoxycarbonyl-2-(4-fluorobenzoyl)pyrrolidine 
• 110529-25-4 (S)-α-<(S)-pyrrolidin-2-yl>benzyl alcohol hydrochloride 
• 152326-82-4 ethyl (S)-(-)-2--1-pyrrolidinecarboxylate 
• 22348-32-9 (S)-diphenylprolinol 
• 110529-26-5 (1S,2'S)-phenyl(1-neopentylpyrrolidin-2-yl)methanol 
• 110529-24-3 (1R,2'S)-phenyl(1-neopentylpyrrolidin-2-yl)methanol 
• 110529-23-2 (αR,2S)-1-methyl-α-phenyl-2-pyrrolidinemethanol 
• 74936-98-4 (1S,2'S)-phenyl(1-methylpyrrolidin-2-yl)methanol 
• 110529-27-6 (S)-1-[(2S)-1-benzylpyrrolidin-2-yl](phenyl)methanol 
• 106202-18-0 ethyl (S)-2-<(S)-α-hydroxybenzyl>pyrrolidine-1-carboxylate 

Relevant articles and documents

Organocatalytic Enantioselective Continuous-Flow Cyclopropanation

A set of six solid-supported diarylprolinol catalysts (varying on the anchoring strategy and the type of polymeric support) has been prepared and applied to the enantioselective cyclopropanation reaction. The selected candidate allows implementation of a long flow experiment (48 h) and generates a library of 12 cyclopropanes by sequential flow experiments. The mildness and utility of the method have enabled a telescoped process in which the outstream is directly used in a Wittig flow reaction.

Stereocontrolled solid-phase synthesis of oligonucleoside H-phosphonates by an oxazaphospholidine approach

(Chemical Equation Presented) Stereodefined oligonucleoside H-phosphonates were synthesized on a solid support using diastereopure nucleoside 3′-O-oxazaphospholidine monomers. Several stereodefined backbone-modified analogues were obtained with the oligonucleoside H-phosphonates as precursors (see scheme; BPRO = protected nucleobase, DMTr = 4,4′- dimethoxytrityl, Th = thymin-1-yl, TfO- = triflate).

Flash vacuum pyrolysis of stabilised phosphorus ylides. Part 17. Preparation of aliphatic amino acid derived γ-alkoxycarbonyl-amino-β-oxo ylides and pyrolysis to give α,β-acetylenic γ-amino acid and GABA analogues

A series of eleven α-aminoacyl stabilised phosphorus ylides 9-19 have been prepared by condensation of N-alkoxycarbonyl protected amino acids with Ph3P = CHCO2Et using a carbodiimide peptide coupling reagent. Upon flash vacuum pyrolysis at 600 °C, these undergo extrusion of Ph3PO to give the corresponding α,β-acetylenic γ-amino esters 21-29, 33 and 34 in moderate yield. In two cases the terminal alkynes 30 and 31 are also formed. The β-aminoacyl ylide 20 from β-alanine similarly gives the α,β-acetylenic δ-amino ester 35 upon pyrolysis. Regioselective addition of HBr to the triple bond of one acetylenic ester 25 was observed giving a mixture of E and Z α-bromoacrylates 36. Hydrogenation of the N-Cbz acetylenic esters 21-23 and 33 results in N-deprotection and hydrogenation of the triple bond to afford the chiral GABA analogues 37-40 in 70 ->95% ee as determined by 19F NMR of their Mosher amides. Fully assigned 13C NMR spectra of all the ylides and acetylenic ester derivatives are presented.