1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone

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Chemical Name:1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone
CAS No.:1253936-83-2
Molecular Formula:C₂₅H₂₃F₃N₆O₂
Molecular Weight:496.492
Hs Code.:

Synonyms:1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone

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Chemical Property of 1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone

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Technology Process of 1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone

There total 6 articles about 1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1253936-66-1
1-[4-(2-bromo-4-trifluoromethyl-phenyl)-piperazin-1-yl]-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone

: 628692-15-9
(2-methoxypyrimidin-5-yl)boronic acid

: 1253936-83-2
1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 100 ℃; for 0.5h; microwave irradiation;

Reference yield:

: 474329-72-1
4-(2-nitro-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1253936-83-2
1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethanol / 20 °C

2.1: isopentyl nitrite / acetonitrile / 0 °C / Inert atmosphere

2.2: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: pH > 12

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 2 h / 20 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 0.5 h / 100 °C / microwave irradiation

With hydrogen; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; 5%-palladium/activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1253936-64-9
4-(2-bromo-4-(trifluoromethyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester

: 1253936-83-2
1-{4-[2-(2-methoxy-pyrimidin-5-yl)-4-trifluoromethyl-phenyl]piperazin-1-yl}-2-pyrrolo[2,3-b]pyridin-1-yl-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: pH > 12

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 2 h / 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 0.5 h / 100 °C / microwave irradiation

With sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; water; N,N-dimethyl-formamide;