4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

Base Information

Chemical Name:4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile
CAS No.:1290138-57-6
Molecular Formula:C₁₆H₁₄N₄O₂
Molecular Weight:294.313
Hs Code.:

Synonyms:4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

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Chemical Property of 4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

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Technology Process of 4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

There total 5 articles about 4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1290138-56-5
4-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde

: 1290138-57-6
4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

: 1290138-58-7
3-(3-chloro-4-hydroxyphenyl)-4-(3,5-dimethylisoxazol-4-yl)-1-methyl-1H-pyrazole-5-carbonitrile

Guidance literature:: 4-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde; With pyridine; hydroxylamine hydrochloride; In ethanol; at 100 ℃; for 0.05h; microwave irradiation;

With thionyl chloride; at 20 ℃; for 2h;

Reference yield: 68.0%

: C₁₇H₁₈N₄O₃

: 1290138-57-6
4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

: 1290138-58-7
3-(3-chloro-4-hydroxyphenyl)-4-(3,5-dimethylisoxazol-4-yl)-1-methyl-1H-pyrazole-5-carbonitrile

Guidance literature:: C₁₇H₁₈N₄O₃; With thionyl chloride; at 20 ℃; for 2h;

With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃;

With methanol; In dichloromethane;

Reference yield:

: 1290138-54-3
(3-(4-methoxyphenyl)-1-methyl-1H-pyrazol-5-yl)methyl 4-methoxybenzoate

: 1290138-57-6
4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

: 1290138-58-7
3-(3-chloro-4-hydroxyphenyl)-4-(3,5-dimethylisoxazol-4-yl)-1-methyl-1H-pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride / ethyl acetate; tetrahydrofuran / 20 °C

2.1: N-Bromosuccinimide / acetonitrile / 0.67 h / 20 °C

2.2: 20 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 140 °C / Inert atmosphere; microwave irradiation

4.1: hydroxylamine hydrochloride; pyridine / ethanol / 0.05 h / 100 °C / microwave irradiation

4.2: 2 h / 20 °C

With pyridine; N-Bromosuccinimide; lithium borohydride; hydroxylamine hydrochloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; acetonitrile;