4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide

Base Information

Chemical Name:4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide
CAS No.:1290137-93-7
Molecular Formula:C₁₆H₁₇N₅O₃
Molecular Weight:327.343
Hs Code.:

Synonyms:4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide

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Chemical Property of 4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide

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Technology Process of 4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide

There total 6 articles about 4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1290138-57-6
4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

: 1290137-94-8
4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide

: 1290137-93-7
4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide

Guidance literature:: With water; hydroxylamine; In dimethyl sulfoxide; at 130 ℃; for 0.166667h;

Reference yield:

: 1290138-54-3
(3-(4-methoxyphenyl)-1-methyl-1H-pyrazol-5-yl)methyl 4-methoxybenzoate

: 1290137-94-8
4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide

: 1290137-93-7
4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium borohydride / ethyl acetate; tetrahydrofuran / 20 °C

2.1: N-Bromosuccinimide / acetonitrile / 0.67 h / 20 °C

2.2: 20 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 140 °C / Inert atmosphere; microwave irradiation

4.1: hydroxylamine hydrochloride; pyridine / ethanol / 0.05 h / 100 °C / microwave irradiation

4.2: 2 h / 20 °C

5.1: water; hydroxylamine / dimethyl sulfoxide / 0.17 h / 130 °C

With pyridine; N-Bromosuccinimide; lithium borohydride; hydroxylamine hydrochloride; water; hydroxylamine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;

Reference yield:

: 1015869-30-3
(3-(4-methoxyphenyl)-1-methyl-1H-pyrazol-5-yl)methanol

: 1290137-94-8
4-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide

: 1290137-93-7
4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / acetonitrile / 0.67 h / 20 °C

1.2: 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 140 °C / Inert atmosphere; microwave irradiation

3.1: hydroxylamine hydrochloride; pyridine / ethanol / 0.05 h / 100 °C / microwave irradiation

3.2: 2 h / 20 °C

4.1: water; hydroxylamine / dimethyl sulfoxide / 0.17 h / 130 °C

With pyridine; N-Bromosuccinimide; hydroxylamine hydrochloride; water; hydroxylamine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; acetonitrile;