3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile

Base Information

Chemical Name:3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile
CAS No.:475272-23-2
Molecular Formula:C₄₁H₃₈N₂O
Molecular Weight:574.766
Hs Code.:

Synonyms:3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile

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Chemical Property of 3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile

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Technology Process of 3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile

There total 10 articles about 3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 475272-22-1
3-(3',3-Dibenzyl-4-hydroxy-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile

: 107-14-2
chloroacetonitrile

: 475272-23-2
3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile

Guidance literature:: With potassium carbonate; In acetone; at 55 ℃;
DOI:10.1002/anie.200462316

Reference yield:

: 475272-05-0
3-(3-isobutyl-4-methoxyphenyl)propanenitrile

: 475272-23-2
3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile

Guidance literature:: Multi-step reaction with 8 steps

1: BBr₃ / CH₂Cl₂ / 20 °C

2: pyridine / 20 °C

3: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide / 110 °C

4: BBr₃ / CH₂Cl₂ / 0 - 20 °C

5: DIEA / CH₂Cl₂

6: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide

7: BBr₃ / CH₂Cl₂

8: K₂CO₃ / acetone / 55 °C

With pyridine; boron tribromide; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetone; 3: Suzuki coupling / 6: Suzuki coupling;
DOI:10.1002/anie.200462316

Reference yield:

: 475272-03-8
4-iodo-2-isobutylanisole

: 475272-23-2
3-(3',3-dibenzyl-4-(cyanomethoxy)-2-isobutyl-1,1':4',1-terphenyl-4-yl)propanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1: Bu₄NCl; NaHCO₃ / Pd(OAc)2 / dimethylformamide / 40 °C

2: Mg / methanol / 20 °C

3: BBr₃ / CH₂Cl₂ / 20 °C

4: pyridine / 20 °C

5: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide / 110 °C

6: BBr₃ / CH₂Cl₂ / 0 - 20 °C

7: DIEA / CH₂Cl₂

8: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide

9: BBr₃ / CH₂Cl₂

10: K₂CO₃ / acetone / 55 °C

With pyridine; tetrabutyl-ammonium chloride; boron tribromide; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 5: Suzuki coupling / 8: Suzuki coupling;
DOI:10.1002/anie.200462316