6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester

Base Information

Chemical Name:6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester
CAS No.:656252-24-3
Molecular Formula:C₃₀H₅₆O₆Si₂
Molecular Weight:568.942
Hs Code.:

6-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-7-[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester

Synonyms:6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester

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Chemical Property of 6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester

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Technology Process of 6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester

There total 6 articles about 6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6290-49-9
methyl methoxyacetate

: 656251-93-3
5-(tert-butyl-dimethyl-silanyloxymethyl)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-hexan-2-one

: 656252-24-3
6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester

Guidance literature:: methyl methoxyacetate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 2.25h;

5-(tert-butyl-dimethyl-silanyloxymethyl)-6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-hexan-2-one; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;
DOI:10.1021/ja030498f

Reference yield:

: 2396-80-7
methyl 5-hexenoate

: 656252-24-3
6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA

1.3: DIBAL-H

2.1: 91 percent / DMAP; Et₃N / CH₂Cl₂ / 24 h / 20 °C

3.1: 74 percent / aq. Cu(OAc)2; PdCl₂; O₂ / N,N-dimethyl-acetamide / 12 h / 20 °C

4.1: LDA / tetrahydrofuran; hexane / 2.25 h / -78 °C

4.2: tetrahydrofuran; hexane / 2.5 h / -78 °C

With dmap; copper diacetate; oxygen; triethylamine; palladium dichloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl acetamide; 3.1: Wacker oxidation;
DOI:10.1021/ja030498f

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 656252-24-3
6-(tert-butyl-dimethyl-silanyloxymethyl)-7-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-3-hydroxy-2-methoxy-3-methyl-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / DMAP; Et₃N / CH₂Cl₂ / 24 h / 20 °C

2.1: 74 percent / aq. Cu(OAc)2; PdCl₂; O₂ / N,N-dimethyl-acetamide / 12 h / 20 °C

3.1: LDA / tetrahydrofuran; hexane / 2.25 h / -78 °C

3.2: tetrahydrofuran; hexane / 2.5 h / -78 °C

With dmap; copper diacetate; oxygen; triethylamine; palladium dichloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl acetamide; 2.1: Wacker oxidation;
DOI:10.1021/ja030498f