Methyl 8-azabicyclo[3.2.1...

Base Information

Chemical Name:Methyl 8-azabicyclo[3.2.1...
CAS No.:179022-43-6
Molecular Formula:C₉H₁₅NO₂*ClH
Molecular Weight:205.685
Hs Code.:
Mol file:179022-43-6.mol

Synonyms:methyl 8-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-8-aza-bicyclo[3.2.1]octane-3-carboxylate

Suppliers and Price of Methyl 8-azabicyclo[3.2.1...

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
methyl8-azabicyclo[3.2.1]octane-3-carboxylatehydrochloride
100mg
$ 240.00

SynQuest Laboratories
Methyl 8-azabicyclo[3.2.1]octane-3-carboxylate hydrochloride
250 mg
$ 225.00

SynQuest Laboratories
Methyl 8-azabicyclo[3.2.1]octane-3-carboxylate hydrochloride
1 g
$ 675.00

Matrix Scientific
Methyl 8-azabicyclo[3.2.1]octane-3-carboxylate hydrochloride
1g
$ 983.00

Crysdot
Methyl8-azabicyclo[3.2.1]octane-3-carboxylatehydrochloride 95+%
1g
$ 387.00

Chemenu
methyl8-azabicyclo[3.2.1]octane-3-carboxylatehydrochloride 95%
10g
$ 1767.00

American Custom Chemicals Corporation
METHYL-8-AZABICYCLO[3.2.1]OCTANE-3-CARBOXYLATE HYDROCHLORIDE 95.00%
5MG
$ 500.58

Ambeed
Methyl8-azabicyclo[3.2.1]octane-3-carboxylatehydrochloride 95%
5g
$ 636.00

Ambeed
Methyl8-azabicyclo[3.2.1]octane-3-carboxylatehydrochloride 95%
250mg
$ 119.00

Ambeed
Methyl8-azabicyclo[3.2.1]octane-3-carboxylatehydrochloride 95%
100mg
$ 70.00

Total 17 raw suppliers

Chemical Property of Methyl 8-azabicyclo[3.2.1...

Chemical Property:

Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

methyl8-azabicyclo[3.2.1]octane-3-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methyl 8-azabicyclo[3.2.1...

There total 5 articles about Methyl 8-azabicyclo[3.2.1... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 8-tert-butyl 3-methyl 8-azabicyclo[3.2.1]octane-3,8-dicarboxylate

: 179022-43-6
methyl 8-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-8-aza-bicyclo[3.2.1]octane-3-carboxylate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 3h;

Reference yield:

: 185099-67-6
Boc-tropinone

: 179022-43-6
methyl 8-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-8-aza-bicyclo[3.2.1]octane-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: -78 - 20 °C

2.1: dmap; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 5 h / 120 °C / Inert atmosphere; Sealed tube

3.1: caesium carbonate / acetonitrile / 0 °C

3.2: 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 4137.29 Torr

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C

With hydrogenchloride; dmap; 1,1'-bis-(diphenylphosphino)ferrocene; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;

Reference yield:

: 185099-68-7,1245646-51-8
tert‐butyl 3‐(trifluoromethanesulfonyloxy)‐8‐azabicyclo[3.2.1]oct‐2‐ene‐8‐carboxylate

: 179022-43-6
methyl 8-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-8-aza-bicyclo[3.2.1]octane-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 5 h / 120 °C / Inert atmosphere; Sealed tube

2.1: caesium carbonate / acetonitrile / 0 °C

2.2: 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 4137.29 Torr

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C

With hydrogenchloride; dmap; 1,1'-bis-(diphenylphosphino)ferrocene; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; water; acetonitrile;