isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate

Base Information

Chemical Name:isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate
CAS No.:1548745-34-1
Molecular Formula:C₂₉H₃₅ClF₃NO₃
Molecular Weight:538.05
Hs Code.:

Synonyms:isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate

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Chemical Property of isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate

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Technology Process of isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate

There total 5 articles about isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 546-68-9
titanium(IV) isopropylate

: 1544009-73-5
8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthaldehyde

: 179022-43-6
methyl 8-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-8-aza-bicyclo[3.2.1]octane-3-carboxylate

: 1548745-34-1
isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate

Guidance literature:: titanium(IV) isopropylate; 8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthaldehyde; methyl 8-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-8-aza-bicyclo[3.2.1]octane-3-carboxylate; With triethylamine; In tetrahydrofuran; at 100 ℃; for 2h; Microwave irradiation;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 100 ℃; for 2h; Sealed tube;

Reference yield:

: 1266120-65-3
4-(trifluoromethyl)cyclohexyl methanesulfonate

: 1548745-34-1
isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 1 h / -78 °C

3.1: N-chloro-succinimide; trifluoroacetic acid / acetonitrile / 16 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 2 h / 100 °C / Microwave irradiation

4.2: 2 h / 100 °C / Sealed tube

With N-chloro-succinimide; n-butyllithium; caesium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 116230-30-9
7-bromonaphthalen-2-ol

: 1548745-34-1
isopropyl 8-((8-chloro-7-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octane-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 1 h / -78 °C

3.1: N-chloro-succinimide; trifluoroacetic acid / acetonitrile / 16 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 2 h / 100 °C / Microwave irradiation

4.2: 2 h / 100 °C / Sealed tube

With N-chloro-succinimide; n-butyllithium; caesium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetonitrile;