tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate
• CAS No.: 1600504-72-0
• Molecular Formula: C₃₁H₂₅FN₂O₄
• Molecular Weight: 508.549

Synonyms:tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate

Chemical Property of tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate

There total 4 articles about tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + 1-(4-fluorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione (135276-47-0) → tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate (1600504-72-0)

Guidance literature:

With pyridine; dmap; dicyclohexyl-carbodiimide; at 20 - 50 ℃;

DOI:10.1016/j.bcp.2014.02.013

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate (1600504-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 25 °C

2: pyridine; potassium hydroxide / 60 °C

3: dicyclohexyl-carbodiimide; dmap; pyridine / 20 - 50 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; potassium hydroxide;

DOI:10.1016/j.bcp.2014.02.013

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → tert-butyl 3-((1-(4-fluorophenyl)-9-oxo-2,9-dihydrochromeno[2,3-c]pyrrol-3-yl)methyl)-1H-indole-1-carboxylate (1600504-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 25 °C

2: pyridine; potassium hydroxide / 60 °C

3: dicyclohexyl-carbodiimide; dmap; pyridine / 20 - 50 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; potassium hydroxide;

DOI:10.1016/j.bcp.2014.02.013

upstream raw materials:

3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester

1-(4-fluorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione

o-hydroxyacetophenone

4-fluorobenzoyl chloride

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