3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one

Base Information

Chemical Name:3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one
CAS No.:1206791-27-6
Molecular Formula:C₂₈H₃₇N₃O₃
Molecular Weight:463.62
Hs Code.:

Synonyms:3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one

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Chemical Property of 3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one

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Technology Process of 3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one

There total 4 articles about 3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.9%

: 99513-17-4
5-bromo-1,2-dimethyl-1H-benzo[d]imidazole

: 1206791-31-2
6-(2-hydroxy-2-methylpropyl)-6-isopropyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one

: 1206791-27-6
3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 3-((S)-1-(4-bromophenyl)ethyl)-6-isopropyl-6-(2-methylallyl)-1,3-oxazinan-2-one

: 1206791-27-6
3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: lithium triethylborohydride / tetrahydrofuran / 22 h / 0 - 13 °C / Inert atmosphere

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 90 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 2 h / 100 °C / Inert atmosphere

With potassium acetate; lithium triethylborohydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 1206791-29-8
3-((S)-1-(4-bromophenyl)ethyl)-6-isopropyl-6-((2-methyloxiran-2-yl)methyl)-1,3-oxazinan-2-one

: 1206791-27-6
3-{(S)-1-[4-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)phenyl]ethyl}-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-1,3-oxazinan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium triethylborohydride / tetrahydrofuran / 22 h / 0 - 13 °C / Inert atmosphere

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 90 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 2 h / 100 °C / Inert atmosphere

With potassium acetate; lithium triethylborohydride; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; toluene;