(S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester

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Chemical Name:(S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester
CAS No.:187806-90-2
Molecular Formula:C₂₂H₃₂N₂O₆
Molecular Weight:420.506
Hs Code.:

Synonyms:(S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester

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Chemical Property of (S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester

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Technology Process of (S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester

There total 1 articles about (S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 187806-89-9
(S)-2-((S)-4-tert-Butoxycarbonylamino-3-oxo-pentanoylamino)-propionic acid benzyl ester

: 74-88-4
methyl iodide

: 187806-90-2
(S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1) 0 deg C, 6 h; 2) 25 deg C, 16 h;
DOI:10.1021/ja963857y

Reference yield:

: 187806-90-2
(S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester

: 187807-05-2
C₆₂H₉₆N₈O₁₅

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / H₂ / Pd/C

2: 45 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate, N,N-diisopropylethylamine / dimethylformamide / 20 h

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/ja963857y

Reference yield:

: 187806-90-2
(S)-2-((S)-4-tert-Butoxycarbonylamino-2,2-dimethyl-3-oxo-pentanoylamino)-propionic acid benzyl ester

: C₅₀H₈₂N₈O₁₃*C₂HF₃O₂

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / H₂ / Pd/C

2: 45 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate, N,N-diisopropylethylamine / dimethylformamide / 20 h

3: 100 percent / H₂ / Pd

4: 91 percent

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; palladium; In N,N-dimethyl-formamide;
DOI:10.1021/ja963857y