5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one

Base Information

• Chemical Name: 5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one
• CAS No.: 136058-65-6
• Molecular Formula: C₂₃H₁₈N₂O₄S
• Molecular Weight: 418.473
• Mol file: 136058-65-6.mol

Synonyms:5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one

Chemical Property of 5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one

There total 1 articles about 5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thio-2,4-oxazolidinedione (2346-24-9) + 4-[3-(5-Methyl-2-phenyl-4-oxazolyl)propionyl]benzaldehyde (125531-53-5) → 5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one (136058-65-6)

Guidance literature:

With sodium acetate; at 120 ℃; for 1.5h; under 0.1 Torr;

DOI:10.1021/jm00109a003

Reference yield:

5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one (136058-65-6) → 5-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-benzyl}-oxazolidine-2,4-dione (132672-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid / dimethylformamide / 2.5 h / Ambient temperature

2: H₂ / 10percent Pd/C / tetrahydrofuran / 2068.6 Torr / Ambient temperature

With hydrogen; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00109a003

Reference yield:

5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one (136058-65-6) → 5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-oxazolidine-2,4-dione (136058-66-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; for 2.5h; Ambient temperature;

DOI:10.1021/jm00109a003

upstream raw materials:

2-thio-2,4-oxazolidinedione

4-[3-(5-Methyl-2-phenyl-4-oxazolyl)propionyl]benzaldehyde

Downstream raw materials:

5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-oxazolidine-2,4-dione

5-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-benzyl}-oxazolidine-2,4-dione