125531-53-5

Upstream product

• 103788-61-0 (5-methyl-2-phenyl-4-oxazolyl)methyl chloride 
• 125532-07-2 ethyl 2-<4-(diethoxymethyl)benzoyl>acetate 
• 125532-06-1 4-(diethoxymethyl)acetophenone 
• 125532-05-0 1-<4-(diethoxymethyl)phenyl>ethanol 
• 81172-89-6 terephthalaldehyde mono(diethylacetal) 

Downstream Products

• 136058-65-6 5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-2-thioxo-oxazolidin-4-one 
• 125531-47-7 5-<<4-<3-(5-methyl-2-phenyl-4-oxazolyl)propionyl>-phenyl>methylene>thiazolidine-2,4-dione 
• 162705-50-2 4-(5-methyl-2-phenyl-4-oxazolepropionyl)cinnamaldehyde 
• 141200-53-5 5-<4-<3-(5-methyl-2-phenyl-4-oxazolyl)-1-propenyl>-benzyl>thiazolidine-2,4-dione 
• 125532-03-8 5-<4-<3-(5-methyl-2-phemyl-4-oxazolyl)propyl>benzyl>-thiazolidine-2,4-dione 
• 141200-24-0 Darglitazone 
• 125531-74-0 5-<4-<3-(5-methyl-2-phenyl-4-oxazolyl)-1-hydroxypropyl>benzyl>thiazolidine-2,4-dione 
• 125549-29-3 5-{4-[1-[(Z)-Hydroxyimino]-3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]-benzyl}-thiazolidine-2,4-dione 
• 125532-04-9 5-<4-<3-(5-methyl-2-phenyl-4-oxazolyl)-1-(methoxyimino)propyl>benzyl>thiazolidine-2,4-dione 
• 141200-79-5 5-{4-[1-[(Z)-Benzyloxyimino]-3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]-benzyl}-thiazolidine-2,4-dione 
• 132672-21-0 5-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-benzyl}-oxazolidine-2,4-dione 
• 136058-66-7 5-[1-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl]-phenyl}-meth-(Z)-ylidene]-oxazolidine-2,4-dione 
• 162705-24-0 5-[3-[4-[3-(5-methyl-2-phenyl-4-oxazolyl)propionyl]phenyl]propyl]-2,4-oxazolidinedione 
• 162705-25-1 5-(3-{4-[1-hydroxy-3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]-phenyl}-propyl)-oxazolidine-2,4-dione 

Relevant academic research and scientific papers

Novel Thiazolidine-2,4-diones as Potent Euglycemic Agents

A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety.These compounds lower blood glucose levels in the genetically obese and insulin-r

Hypoglycemic thiazolidinedione derivatives

Hypoglycemic thiazolidine-2,4-derivatives STR1 wherein the dotted line represents a bond or no bond; V is --CH=CH--, --N=CH--, --CH=N-- or S; W is CH2, CHOH, CO, C=NOR or --CH=CH--; X is S, O, NR1, --CH=N-- or --N=CH--; Y is CH or N; Z is hydrogen, (C1 -C7)alkyl, (C3 -C7)cycloalkyl, phenyl, naphtyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C1 -C3)alkyl, trifluoromethyl, (C1 -C3)alkoxy, fluoro, chloro or bromo; Z1 is hydrogen or (C1 -C3)alkyl; R is hydrogen or methyl; and n is 1, 2 or 3; a pharamceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains basic nitrogen.

Hypoglycemic thiazolidinedione derivatives

Hypoglycemic thiazolidine-2,4-dione derivatives wherein the dotted line represents a bond or no bond;, V is -CH=CH-, -N=CH-, -CH=N- or S;, W is CH2, CHOH, CO, C=NOR or -CH=CH-;, X is S, O, NR1, -CH=N- or -N=CH-;, Y is CH or N;, Z is hydrogen, (C1-C7)alkyl, (C3-C7)cycloalkyl, phenyl, naphthyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C1-C3)alkyl, trifluoromethyl, (C1-C3)alkoxy, fluoro, chloro or bromo;, Z1 is hydrogen or (C1-C3)alkyl;, R is hydrogen or methyl; and, n is 1, 2 or 3;, a pharmaceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen.