4-Methyl-2-(1H-pyrrole-1-yl)-5-phenylfuran-3-carbonitrile

Base Information

• Chemical Name: 4-Methyl-2-(1H-pyrrole-1-yl)-5-phenylfuran-3-carbonitrile
• CAS No.: 220696-23-1
• Molecular Formula: C₁₆H₁₂N₂O
• Molecular Weight: 248.284
• DSSTox Substance ID: DTXSID301202400
• Nikkaji Number: J1.048.051E
• Mol file: 220696-23-1.mol

Synonyms:DTXSID301202400;4-Methyl-5-phenyl-2-(1H-pyrrol-1-yl)-3-furancarbonitrile;4-Methyl-2-(1H-pyrrole-1-yl)-5-phenylfuran-3-carbonitrile;220696-23-1

Chemical Property of 4-Methyl-2-(1H-pyrrole-1-yl)-5-phenylfuran-3-carbonitrile

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 248.094963011
• Heavy Atom Count: 19
• Complexity: 349

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(OC(=C1C#N)N2C=CC=C2)C3=CC=CC=C3

Technology Process of 4-Methyl-2-(1H-pyrrole-1-yl)-5-phenylfuran-3-carbonitrile

There total 2 articles about 4-Methyl-2-(1H-pyrrole-1-yl)-5-phenylfuran-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 2-amino-4-methyl-5-phenylfuran-3-carbonitrile (220696-21-9) → 4-methyl-5-phenyl-2-(1-pyrrolyl)-3-furonitrile (220696-23-1)

Guidance literature:

With 4-chlorpyridine hydrochloride; In 1,4-dioxane; at 70 ℃; for 1.5h;

DOI:10.1002/jhet.5570350613

Reference yield:

2-bromo-1-phenyl-1-propanone (2114-00-3) → 4-methyl-5-phenyl-2-(1-pyrrolyl)-3-furonitrile (220696-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / Et₂NH / dimethylformamide / 1 h / Ambient temperature

2: 84 percent / 4-chloropyridinium chloride / dioxane / 1.5 h / 70 °C

With 4-chlorpyridine hydrochloride; diethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570350613

Reference yield: 77.0%

4-methyl-5-phenyl-2-(1-pyrrolyl)-3-furonitrile (220696-23-1) → 1-<4-methyl-5-phenyl-2-(1-pyrrolyl)-3-furyl>methylamine (220696-25-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Heating;

DOI:10.1002/jhet.5570350613

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

2-amino-4-methyl-5-phenylfuran-3-carbonitrile

2-bromo-1-phenyl-1-propanone

Downstream raw materials:

1-<4-methyl-5-phenyl-2-(1-pyrrolyl)-3-furyl>methylamine