(1S,2S)-(+)-trans-2-methylcyclohexanecarboxaldehyde

Base Information

• Chemical Name: (1S,2S)-(+)-trans-2-methylcyclohexanecarboxaldehyde
• CAS No.: 97276-80-7
• Molecular Formula: C₈H₁₄O
• Molecular Weight: 126.199
• Mol file: 97276-80-7.mol

Synonyms:(1S,2S)-(+)-trans-2-methylcyclohexanecarboxaldehyde

Chemical Property of (1S,2S)-(+)-trans-2-methylcyclohexanecarboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-(+)-trans-2-methylcyclohexanecarboxaldehyde

There total 18 articles about (1S,2S)-(+)-trans-2-methylcyclohexanecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-methylcyclohex-1-ene (591-49-1) + carbon monoxide (201230-82-2) → trans-2-methylcyclohexanecarbaldehyde (13076-15-8,13377-49-6,50778-40-0,97276-80-7)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); C₃₇H₅₀NO₄P; hydrogen; In toluene; at 100 ℃; for 12h; under 15001.5 Torr; regioselective reaction; Autoclave;

DOI:10.1021/acs.orglett.9b01639

Reference yield: 30.0%

cis-1-hydroxymethyl-2-methylcyclohexane (3937-45-9) → (1S*,2R*)-2-methylcyclohexanecarbaldehyde (13076-15-8,13377-49-6,50778-40-0,97276-80-7)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.0c00359

Reference yield:

1-methylcyclohex-1-ene (591-49-1) + carbon monoxide (201230-82-2) → trans-2-methylcyclohexanecarbaldehyde (13076-15-8,13377-49-6,50778-40-0,97276-80-7) + cyclohexanecarbaldehyde (2043-61-0)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); C₃₇H₅₀NO₄P; hydrogen; In toluene; at 100 ℃; for 12h; under 15001.5 Torr; Pressure; Concentration; regioselective reaction; Autoclave;

DOI:10.1021/acs.orglett.9b01639

upstream raw materials:

methoxymethyl phenyl sulfide

(1'S,2'S)-(+)-2-(trans-2'-methylcyclohexyl)-1,3,2-dioxaborinane

thiophenol

(+/-)-trans-2-methyl-cyclohexanecarbaldehyde-semicarbazone

Downstream raw materials:

1-bromo-2-methyl-cyclohexanecarbaldehyde

(1S,2S)-(+)-trans-(2-methylcyclohexyl)methanol

trans-1-methyl-2-vinylcyclohexane

cis-1-methyl-2-vinylcyclohexane