N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide

Base Information

Chemical Name:N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide
CAS No.:1334921-26-4
Molecular Formula:C₂₄H₁₈F₃N₃O₂S
Molecular Weight:469.487
Hs Code.:

Synonyms:N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide

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Technology Process of N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide

There total 6 articles about N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 14254-57-0
4-(chlorocarbonyl)pyridine

: 1334922-54-1
4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-amine

: 1334921-26-4
N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm401990s

Reference yield: 87.0%

: 1334921-26-4
N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide

Guidance literature:

Reference yield:

: 35887-71-9
1-(4-chloro-2,6-dimethylphenyl)ethanone

: 1334921-26-4
N-(4-{2,6-dimethyl-4-[4-(trifluoromethyl)phenoxy]phenyl}-thiazol-2-yl)pyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate; tert-butyl XPhos; palladium diacetate / toluene / 2 h / 100 °C / Inert atmosphere

2: tetra-N-butylammonium tribromide / acetonitrile / 1.33 h / 20 °C

3: ethanol / 1 h / Reflux

4: dmap / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; potassium phosphate; palladium diacetate; tetra-N-butylammonium tribromide; tert-butyl XPhos; In ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm401990s