Ethanone, 1-(4-amino-2,6-dimethylphenyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(4-amino-2,6-dimethylphenyl)- (9CI)
• CAS No.: 83759-88-0
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2922399090
• Mol file: 83759-88-0.mol

Synonyms:1-Acetyl-4-amino-2,6-dimethylbenzene

Chemical Property of Ethanone, 1-(4-amino-2,6-dimethylphenyl)- (9CI)

Chemical Property:

• PSA: 43.09000
• LogP: 2.66940

Purity/Quality:

99%min ^*data from raw suppliers

1-(4-Amino-2,6-dimethyl-phenyl)-ethanone 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(4-amino-2,6-dimethylphenyl)- (9CI)

There total 4 articles about Ethanone, 1-(4-amino-2,6-dimethylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(4-acetyl-3,5-dimethylphenyl)acetamide (100923-73-7) → 1-(4-amino-2,6 dimethylphenyl)ethanone (83759-88-0)

Guidance literature:

With hydrogenchloride; In water; at 95 ℃; for 20h;

DOI:10.1039/d0dt03198d

Reference yield:

N-acetyl-3,5-dimethylaniline (2050-45-5) → 1-(4-amino-2,6 dimethylphenyl)ethanone (83759-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃; CS₂

2: aq.-ethanolic HCl

With hydrogenchloride; carbon disulfide; aluminium trichloride;

DOI:10.1021/jo01133a004

Reference yield:

3,5-dimethylaminoaniline (108-69-0) → 1-(4-amino-2,6 dimethylphenyl)ethanone (83759-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dichloromethane / 2.5 h / 20 °C / Cooling with ice

2: aluminum (III) chloride / dichloromethane / 3 h / 0 - 5 °C / Cooling with ice

3: hydrogenchloride / water / 2 h / 80 - 100 °C

With hydrogenchloride; aluminum (III) chloride; potassium carbonate; In dichloromethane; water;

DOI:10.1039/c4md00573b

upstream raw materials:

N-(4-acetyl-3,5-dimethylphenyl)acetamide

3,5-dimethylaminoaniline

acetyl chloride

N-acetyl-3,5-dimethylaniline

Downstream raw materials:

(Acetyl-4-dimethyl-3.5-phenyl)-(methoxy-4'-phenyl)-amin

1-acetyl-4-fluoro-2,6-dimethylbenzene

1-(4-iodo-2,6-dimethylphenyl)ethanone

1-(4-ethoxy-2,6-dimethylphenyl)ethanone

Refernces

• 1、 -. "4 - (4 - ((9H - purine - 6 - yl) thio) phenyl) thiazolyl - 2 - amine derivative and its preparation and use". Paragraph 0131; 0140; 0141; 0142. . Retrieved 2017/08/04.