1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline

Base Information

Chemical Name:1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline
CAS No.:1586765-08-3
Molecular Formula:C₂₀H₁₈ClN₅
Molecular Weight:363.849
Hs Code.:

Synonyms:1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline

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Chemical Property of 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline

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Technology Process of 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline

There total 4 articles about 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1586765-18-5
1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-4,9-dihydro-3H-β-carboline

: 1586765-08-3
1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline

Guidance literature:: With sodium tetrahydroborate; In methanol; for 1h; Reflux;
DOI:10.1134/S1070428014020225

Reference yield:

: 88958-17-2
1-phenyl-5-methyl-1H-1,2,3-triazole-4-carboxylic acid chloride

: 1586765-08-3
1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1,2-dichloro-ethane; dichloromethane / 12 h / 25 °C

2: trichlorophosphate; phosphorus pentoxide / toluene / 12 h / 110 °C

3: sodium tetrahydroborate / methanol / 1 h / Reflux

With sodium tetrahydroborate; phosphorus pentoxide; potassium carbonate; trichlorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane; toluene; 2: |Bischler-Napieralski Reaction;
DOI:10.1134/S1070428014020225

Reference yield:

: 20725-32-0
5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxylic acid

: 1586765-08-3
1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-chloro-2,3,4,9-tetrahydro-1H-β-carboline

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: potassium carbonate / 1,2-dichloro-ethane; dichloromethane / 12 h / 25 °C

3: trichlorophosphate; phosphorus pentoxide / toluene / 12 h / 110 °C

4: sodium tetrahydroborate / methanol / 1 h / Reflux

With sodium tetrahydroborate; thionyl chloride; phosphorus pentoxide; potassium carbonate; trichlorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane; toluene; 3: |Bischler-Napieralski Reaction;
DOI:10.1134/S1070428014020225