2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide

Base Information

• Chemical Name: 2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide
• CAS No.: 148564-94-7
• Molecular Formula: C₁₈H₁₄F₃NO₃
• Molecular Weight: 349.309
• Mol file: 148564-94-7.mol

Synonyms:2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide

Chemical Property of 2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide

There total 1 articles about 2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(4-methoxyphenyl)-2-propyn-1-ol (19115-30-1) + 2,2,2-trifluoro-N-(2-iodophenyl)acetamide (143321-89-5) → 2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide (148564-94-7)

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(97)00852-1

Reference yield: 65.0%

2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide (148564-94-7) → [E]-3-(p-methoxyphenyl)-1-(2-trifluoroacetamidophenyl)prop-2-en-1-one (197730-11-3)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 48h; Ambient temperature;

DOI:10.1016/0040-4039(93)85025-R

Reference yield: 63.5%

2-[3-hydroxy-3-(p-methoxyphenyl)prop-1-ynyl]trifluoroacetanilide (148564-94-7) → 2-(4-methoxyphenyl)quinoline (16032-40-9)

Guidance literature:

With sodium ethanolate; In ethanol; for 5h; Heating;

DOI:10.1016/0040-4039(93)85025-R

upstream raw materials:

1-(4-methoxyphenyl)-2-propyn-1-ol

2,2,2-trifluoro-N-(2-iodophenyl)acetamide

Downstream raw materials:

2-(4-methoxyphenyl)quinoline

[E]-3-(p-methoxyphenyl)-1-(2-trifluoroacetamidophenyl)prop-2-en-1-one

(E)-1-(2-aminophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one