1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide

Base Information

Chemical Name:1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide
CAS No.:212322-33-3
Molecular Formula:C₂₅H₂₈N₂O₅
Molecular Weight:436.508
Hs Code.:

Synonyms:1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide

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Chemical Property of 1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide

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Technology Process of 1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide

There total 5 articles about 1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 24424-99-5
di-tert-butyl dicarbonate

: C₂₁H₂₂N₂O₃S

: 212322-33-3
1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide

Guidance literature:: C₂₁H₂₂N₂O₃S; In ethanol; at 20 ℃; for 2h;

di-tert-butyl dicarbonate; With dmap; In tetrahydrofuran; at 50 ℃; for 2.5h;

Reference yield:

: 212322-63-9
4-nitrobenzoic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide

: 212322-33-3
1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 2250.23 Torr

2.1: tert-butylhypochlorite / dichloromethane / 2 h / -70 °C

2.2: -78 - 20 °C

3.1: Raney nickel / ethanol / 2 h / 20 °C

3.2: 2.5 h / 50 °C

With tert-butylhypochlorite; palladium 10% on activated carbon; hydrogen; In methanol; ethanol; dichloromethane;

Reference yield:

: 21911-84-2
methyl 3-(phenylamino)propanoate

: 212322-33-3
1-tert-Butoxycarbonyl-2-methyl-indol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / Reflux

1.2: 1 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 2250.23 Torr

3.1: tert-butylhypochlorite / dichloromethane / 2 h / -70 °C

3.2: -78 - 20 °C

4.1: Raney nickel / ethanol / 2 h / 20 °C

4.2: 2.5 h / 50 °C

With thionyl chloride; tert-butylhypochlorite; palladium 10% on activated carbon; hydrogen; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;