3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester

Base Information

Chemical Name:3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester
CAS No.:317318-29-9
Molecular Formula:C₂₃H₂₂F₃NO₃S
Molecular Weight:449.494
Hs Code.:

Synonyms:3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester

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Chemical Property of 3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester

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Technology Process of 3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester

There total 6 articles about 3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175277-03-9
4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

: 317318-29-9
3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / LiAlH₄ / tetrahydrofuran / 20 °C

2: 90 percent / MeSO₂Cl; Et₃N / CH₂Cl₂ / 0 °C

3: Cs₂CO₃ / acetonitrile / 16 h / 20 °C

With lithium aluminium tetrahydride; caesium carbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile; 3: Williamson reaction;
DOI:10.1016/S0960-894X(03)00207-5

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 317318-29-9
3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / P(o-Tol)3; P₂(dba)3; Et₃N / dimethylformamide / 110 °C

2: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 20 °C

3: Cs₂CO₃ / acetonitrile / 16 h / 20 °C

With P₂(dba)3; hydrogen; caesium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Heck coupling / 3: Williamson reaction;
DOI:10.1016/S0960-894X(03)00207-5

Reference yield:

: 317319-05-4
3-(4-hydroxy-2-methylphenyl)acryl acid methyl ester

: 317318-29-9
3-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 20 °C

2: Cs₂CO₃ / acetonitrile / 16 h / 20 °C

With hydrogen; caesium carbonate; palladium on activated charcoal; In ethyl acetate; acetonitrile; 2: Williamson reaction;
DOI:10.1016/S0960-894X(03)00207-5