(2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol

Base Information

Chemical Name:(2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol
CAS No.:858917-07-4
Molecular Formula:C₂₁H₃₆O₄Si
Molecular Weight:380.6
Hs Code.:

Synonyms:(2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol

Suppliers and Price of (2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol

There total 7 articles about (2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 858917-00-7
ethyl (2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-enoate

: 858917-07-4
(2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃;
DOI:10.1021/ol051040g

Reference yield:

: 121289-23-4
p-methoxybenzyloxyacetaldehyde

: 858917-07-4
(2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: (R)-BINOL; Ti(OiPr)4; TFA / molecular sieves 4 Angstroem / CH₂Cl₂ / 120 h / -20 °C

2: 97 percent / imidazole / dimethylformamide / 8 h / 20 °C

3: NaH / tetrahydrofuran / 2 h / 20 °C

4: 93 percent / LAH / diethyl ether / 0 - 20 °C

With 1H-imidazole; titanium(IV) isopropylate; lithium aluminium tetrahydride; (R)-1,1'-Bi-2-naphthol; sodium hydride; trifluoroacetic acid; 4 A molecular sieve; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol051040g

Reference yield:

: 131489-39-9
1-<(trimethylsilyl)oxy>-1-ethoxy-3-methyl-1,3-butadiene

: 858917-07-4
(2E,5R)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hex-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: [Cu(R,R)-PhPyBox)](SbF₆)2*2H₂₀ / CH₂Cl₂ / -78 °C

1.2: aq. HCl / ethyl acetate / 20 °C

2.1: imidazol / dimethylformamide / 20 °C

3.1: LiAlH₄ / diethyl ether / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; [Cu(R,R-C₅H₃N(C₃H₃ON(C₆H₅))2)(H₂O)2][SbF₆]2; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja026235n