3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

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Chemical Name:3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one
CAS No.:1548334-63-9
Molecular Formula:C₂₁H₁₇ClFN₇O
Molecular Weight:437.864
Hs Code.:

Synonyms:3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

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Chemical Property of 3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

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Technology Process of 3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

There total 10 articles about 3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.2%

: 1548340-37-9
3-(1-aminopropyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

: 87-42-3
6-chloropurine

: 1548334-63-9
3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: With triethylamine; In butan-1-ol; for 16h; Inert atmosphere; Reflux;

Reference yield:

: 872-32-2
2-methyl-1H-pyrroline

: 1548334-63-9
3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-chloro-succinimide / tetrahydrofuran / 1.5 h / 55 - 70 °C / Reflux

2.1: methanol / 2 h / 20 °C / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

3.2: 0.5 h / 0 - 20 °C

4.1: ammonia / methanol / 16 h / 130 °C / Sealed tube

5.1: copper diacetate; pyridine / dichloromethane / 16 h / 20 °C / Molecular sieve

6.1: selenium(IV) oxide / 1,4-dioxane / 2 h / Reflux

7.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

8.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 50 - 60 °C

9.1: triphenylphosphine; ammonium chloride / tetrahydrofuran / 16 h / 50 - 60 °C

10.1: triethylamine / butan-1-ol / 16 h / Inert atmosphere; Reflux

With pyridine; selenium(IV) oxide; N-chloro-succinimide; diphenyl phosphoryl azide; ammonia; copper diacetate; sodium hydride; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; butan-1-ol;

Reference yield:

: 226409-94-5
4,4-dichloro-5-(trichloromethyl)-3,4-dihydro-2H-pyrrole

: 1548334-63-9
3-(1-(9H-purin-6-ylamino)propyl)-8-chloro-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: methanol / 2 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

2.2: 0.5 h / 0 - 20 °C

3.1: ammonia / methanol / 16 h / 130 °C / Sealed tube

4.1: copper diacetate; pyridine / dichloromethane / 16 h / 20 °C / Molecular sieve

5.1: selenium(IV) oxide / 1,4-dioxane / 2 h / Reflux

6.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

7.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 50 - 60 °C

8.1: triphenylphosphine; ammonium chloride / tetrahydrofuran / 16 h / 50 - 60 °C

9.1: triethylamine / butan-1-ol / 16 h / Inert atmosphere; Reflux

With pyridine; selenium(IV) oxide; diphenyl phosphoryl azide; ammonia; copper diacetate; sodium hydride; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; butan-1-ol;