872-32-2Relevant articles and documents
Intramolecular cyclization of aminoalkynes catalyzed by PdMo 3S4 cubane clusters
Takei, Izuru,Enta, Yutaka,Wakebe, Youhei,Suzuki, Toshiaki,Hidai, Masanobu
, p. 590 - 591 (2006)
PdMo3S4 cubane clusters [(Cp*Mo) 3(μ3-S)4Pd(L)][PF6] (Cp* = η5-C5Me5; L = dba (2), ma (3); dba = dibenzylideneacetone, ma = maleic anhydride) showed high catalytic activity for the intramolecular hydroamination of aminoalkynes to afford the corresponding cyclic imines in good yields under mild conditions. A molecular structure of 3 has been determined by X-ray diffraction study. Copyright
Inhibitors of polyamine biosynthesis. 3. (±) 5 amino 2 hydrazino 2 methylpentanoic acid, an inhibitor of ornithine decarboxylase
Abdel Monem,Newton,Weeks
, p. 945 - 948 (1975)
(±) 5 Amino 2 hydrazino 2 methylpentanoic acid [α hydrazino α methyl (±) ornithine] was obtained from 1 phthalimidopentan 4 one by treatment with hydrazine and KCN followed by acid hydrolysis. The title compound was found in vitro to be a potent competitive inhibitor of ornithine decarboxylase obtained from the prostate glands of rats. This inhibition was abolished at high concentrations of pyridoxal phosphate. The title compound also blocked the increase in putrescine levels normally observed in bovine lymphocytes transformed by conconavalin A.
Dendrimeric and Corresponding Monometallic Iridium(III) Catalysts Bound to Carbon Nanotubes Used in Hydroamination Transformations
Pernik, Indrek,Desmecht, Antonin,Messerle, Barbara A.,Hermans, Sophie,Riant, Olivier
supporting information, p. 3448 - 3457 (2021/08/30)
This report describes the synthesis of a carbon nanotube-bound dendrimer and three carbon nanotube-bound monometallic complexes and their use as catalysts. The polyamidoamine third generation dendrimer used here incorporates pyrazole-triazole moieties suitable for ligating iridium(III) centres. The monometallic complexes use the same pyrazole-triazole ligands coordinated to an iridium(III) centre. All catalysts were characterized using ICP-AES and XPS to evaluate their metal loadings on the carbon surface with significantly higher relative weight percentage of iridium determined for the denrimeric species. The catalytic activity and practicality of the formed catalysts were tested using two different intramolecular hydroamination reactions.
Synthesis method of 2-methyl pyrroline
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Paragraph 0014; 0016; 0018, (2020/06/16)
The invention discloses a synthesis method of 2-methyl pyrroline. The preparation method comprises the following steps: adding valeryl chloride and phthaloyl potassium salt into a high-boiling-point solvent and carrying out heating reflux for 5 to 15 hours; and S2, after the reaction liquid is cooled, filtering the reaction liquid, concentrating the reaction liquid, adding methanol for pulping toobtain a crude product, adding the crude product obtained in S1 into hydrochloric acid for heating reflux, after the reaction is completed, performing concentrating to dryness, adding water into residual liquid for dissolving, adjusting the pH value to be about 11 by using sodium carbonate, performing extracting for 3-5 times by using dichloromethane, and performing concentrating and drying, and distilling to obtain a product. According to the synthetic method of the 2-methyl pyrroline, disclosed by the invention, the used initial raw materials are easy to obtain, the preparation is convenient, the enlarged production is easy, the intermediate product is stable, and the collection efficiency is high.
A Commercially Available and User-Friendly Catalyst for Hydroamination Reactions under Technical Conditions
Zelenay, Benjamin,Munton, Peter,Tian, Xiaojie,Díez-González, Silvia
, p. 4725 - 4730 (2019/08/01)
The activity of a simple, commercially available copper salt, [Cu(NCMe)4](BF4) in intramolecular hydroamination reactions of alkynes and allenes is presented. Reactions were successfully carried out in technical acetonitrile in the presence of air. While attempts of alkene hydroamination failed, this catalyst was also found active in intermolecular aza-Michael reactions.
