2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile

Base Information

• Chemical Name: 2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile
• CAS No.: 882696-23-3
• Molecular Formula: C₂₆H₄₀ClNOS
• Molecular Weight: 450.129
• Mol file: 882696-23-3.mol

Synonyms:2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile

Chemical Property of 2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile

There total 1 articles about 2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

lithium α-carbanion of propionitrile (150942-96-4) + [chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane (172467-97-9) → 2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile (882696-23-3)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2006.01.161

Reference yield: 90.0%

2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile (882696-23-3) → 1-methyl-2-(toluene-4-sulfinyl)-spiro[2.14]heptadecane-1-carbonitrile (882696-24-4)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2006.01.161

Reference yield:

2-{1-[chloro-(toluene-4-sulfinyl)-methyl]-cyclopentadecyl}-propionitrile (882696-23-3) → 2-bromo-1-methyl-2-(toluene-4-sulfinyl)-spiro[2.14]heptadecane-1-carbonitrile (882696-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / tBuOK / tetrahydrofuran; 2-methyl-propan-2-ol / -78 - 20 °C

2: 85 percent / LDA; CBr₄ / tetrahydrofuran

With carbon tetrabromide; potassium tert-butylate; lithium diisopropyl amide; In tetrahydrofuran; tert-butyl alcohol;

DOI:10.1016/j.tetlet.2006.01.161

upstream raw materials:

lithium α-carbanion of propionitrile

[chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane

Downstream raw materials:

1-methyl-2-(toluene-4-sulfinyl)-spiro[2.14]heptadecane-1-carbonitrile

2-bromo-1-methyl-2-(toluene-4-sulfinyl)-spiro[2.14]heptadecane-1-carbonitrile

2-chloro-1-methyl-2-(toluene-4-sulfinyl)-spiro[2.14]heptadecane-1-carbonitrile