(1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene

Base Information

Chemical Name:(1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene
CAS No.:924298-37-3
Molecular Formula:C₃₂H₄₀O₄Si
Molecular Weight:516.753
Hs Code.:

Synonyms:(1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene

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Chemical Property of (1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene

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Technology Process of (1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene

There total 4 articles about (1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 924298-36-2
(1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-hydroxy-cyclohex-3-ene

: 100-39-0
benzyl bromide

: 924298-37-3
(1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene

Guidance literature:: (1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-hydroxy-cyclohex-3-ene; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 20 ℃; for 25h;
DOI:10.1016/j.tetasy.2006.11.014

Reference yield:

: 924298-34-0
(1R,2R,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-2-p-nitrobenzoyloxy-cyclohex-3-en-1-ol

: 924298-37-3
(1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 93.2 percent / P₂O₅ / 2 h / 20 °C

2.1: 96.6 percent / NaOMe / methanol / 0.83 h / 20 °C

3.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

3.2: 91 percent / Bu₄NI / tetrahydrofuran / 25 h / 20 °C

With sodium methylate; phosphorus pentoxide; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetasy.2006.11.014

Reference yield:

: 924298-35-1
(1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-(methoxymethoxy)-2-p-nitrobenzoyloxy-cyclohex-3-ene

: 924298-37-3
(1R,2S,5S)-5-(tert-butyl-diphenylsilanyloxymethyl)-1-methoxymethoxy-2-benzyloxy-cyclohex-3-ene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96.6 percent / NaOMe / methanol / 0.83 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

2.2: 91 percent / Bu₄NI / tetrahydrofuran / 25 h / 20 °C

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetasy.2006.11.014