methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate

Base Information

Chemical Name:methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate
CAS No.:848667-50-5
Molecular Formula:C₁₁H₁₂F₂O₃
Molecular Weight:230.211
Hs Code.:

Synonyms:methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate

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Technology Process of methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate

There total 5 articles about methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 767352-24-9
methyl 4-(2,5-difluorophenyl)-3-oxobutanoate

: 848667-50-5
methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate

Guidance literature:: With hydrogenchloride; hydrogen; dichloro-R-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl ruthenium; In water; at 60 ℃; for 4 - 5h; under 7757.43 Torr;

Reference yield:

: 767352-24-9
methyl 4-(2,5-difluorophenyl)-3-oxobutanoate

: 848667-50-5
methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate

: (R)-4-(2,5-Difluoro-phenyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: With hydrogenchloride; hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); In methanol; at 60 ℃; under 7757.22 Torr; Title compound not separated from byproducts;
DOI:10.1021/jo048249c

Reference yield:

: 157033-23-3
2,5-difluorophenyl acetyl chloride

: 848667-50-5
methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 4.3 kg / 2,4,6-collidine / CH₂Cl₂ / 3 h / -5 - 0 °C

2: 2.5 h / Heating

3: HCl; H₂ / (S)-BINAP-RuCl₂ / methanol / 60 °C / 7757.22 Torr

With 2,4,6-trimethyl-pyridine; hydrogenchloride; hydrogen; dichloro[(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II); In methanol; dichloromethane;
DOI:10.1021/jo048249c