767352-24-9

Upstream product

• 764667-66-5 5-[1-hydroxy-2-(2,5-difluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 67-56-1 methanol 
• 85068-27-5 2,5-difluorophenylacetic acid 
• 157033-23-3 2,5-difluorophenyl acetyl chloride 

Downstream Products

• 848667-50-5 methyl (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoate 
• 486459-98-7 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid 
• 767352-26-1 N-benzyloxy-4(R)-[1-methyl-(2,5-difluorobenzyl)]-2-oxoazetidine 
• 848667-53-8 (R)-3-Amino-4-(2,5-difluoro-phenyl)-butyric acid methyl ester 
• 848667-51-6 (3S)-4-(2,5-difluorophenyl)-3-hydroxybutanoic acid 

Relevant academic research and scientific papers

Synthesis of a β-amino acid pharmacophore via a β-lactam intermediate

(Chemical Equation Presented) A stereoselective synthesis of (R)-β-amino acid 1 via a β-lactam intermediate is discussed.

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BETA-AMINO ACID AMIDE DIPEPTIDYL PEPTIDASE-IV INHIBITORS

A novel process is provided for the preparation of chiral beta-amino acid amide inhibitors of the dipeptidyl peptidase-IV and the useful intermediates obtained therein. The products resulting from the instant process are inhibitors of dipeptidyl peptidase-IV and thereby useful for the treatment of Type 2 diabetes.