(2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid

Base Information

Chemical Name:(2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid
CAS No.:121778-85-6
Molecular Formula:C₁₅H₂₁NO₆
Molecular Weight:311.335
Hs Code.:

Synonyms:(2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid

Chemical Property:

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Technology Process of (2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid

There total 14 articles about (2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 121778-84-5
tert-butyl ((1R,2R)-1,3-dihydroxy-1-(4-methoxyphenyl)propan-2-yl)carbamate

: 121778-85-6
(2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid

Guidance literature:: With platinum(IV) oxide; oxygen; In 1,4-dioxane; water; at 40 ℃; for 24h;
DOI:10.1016/S0040-4039(00)80712-1

Reference yield:

: C₁₆H₂₃NO₆

: 121778-85-6
(2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.8b01201

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 121778-85-6
(2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaHCO₃

2: 46 percent / PtO₂/O₂ / dioxane; H₂O / 24 h / 40 °C

With platinum(IV) oxide; oxygen; sodium hydrogencarbonate; In 1,4-dioxane; water;
DOI:10.1016/S0040-4039(00)80712-1