1,3-Propanediol, 2-amino-1-(4-methoxyphenyl)-

Base Information

• Chemical Name: 1,3-Propanediol, 2-amino-1-(4-methoxyphenyl)-
• CAS No.: 50731-62-9
• Molecular Formula: C10H15NO3
• Molecular Weight: 197.234
• Mol file: 50731-62-9.mol

Synonyms:(1RS,2RS)-2-Amino-1-(4-methoxy-phenyl)-propan-1,3-diol;(1S,2S)-2-Amino-1-(4-methoxy-phenyl)-propane-1,3-diol;

Chemical Property of 1,3-Propanediol, 2-amino-1-(4-methoxyphenyl)-

Chemical Property:

• Melting Point: 129 - 131 °C (diethyl ether)
• PSA: 75.71000
• LogP: 0.74850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Propanediol, 2-amino-1-(4-methoxyphenyl)-

There total 12 articles about 1,3-Propanediol, 2-amino-1-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

hydroxymethyl-5-(4-methoxy-phenyl)-oxazolidin-2-one → (1R,2R)-(-)-2-amino-1-(4-methoxyphenyl)propane-1,3-diol (50731-62-9)

Guidance literature:

With sodium hydroxide; water; for 0.5h; Heating / reflux;

Reference yield:

1-(4-Methoxy-phenyl)-2-nitro-3-(tetrahydro-pyran-2-yloxy)-propan-1-ol (96040-17-4) → (1RS,2RS)-2-amino-1-(4-methoxy-phenyl)-propane-1,3-diol (50731-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Amberlist / methanol / 2 h / 45 °C

2: H₂ / Raney nickel / ethanol / 20 h / 50 °C / 22800 Torr

With Amberlist; hydrogen; nickel; In methanol; ethanol;

DOI:10.1021/ja00298a033

Reference yield:

Acetic acid (4S,5R)-5-(4-methoxy-phenyl)-2-oxo-oxazolidin-4-ylmethyl ester (121778-80-1) → (1R,2R)-(-)-2-amino-1-(4-methoxyphenyl)propane-1,3-diol (50731-62-9)

Guidance literature:

With barium dihydroxide; In ethanol; at 80 ℃; for 16h;

DOI:10.1016/S0040-4039(00)80712-1

upstream raw materials:

Acetic acid (4S,5R)-5-(4-methoxy-phenyl)-2-oxo-oxazolidin-4-ylmethyl ester

methyl (4S,5R)-5-(4-methoxyphenyl)-2-oxo-1,3-oxazolidine-4-carboxylate

(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoate

(2S)-1-acetoxy-2-tert-butyloxycarbonylamino-3-(4-methoxyphenyl)propane

Downstream raw materials:

tert-butyl ((1R,2R)-1,3-dihydroxy-1-(4-methoxyphenyl)propan-2-yl)carbamate

2-amino-3-hydroxy-3-(4-methoxy-phenyl)-propionic acid

[(4R,5R)-4-(4-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxan-5-yl]-carbamic acid tert-butyl ester

(2S,3R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-(4-methoxyphenyl)propanoic acid

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