N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide

Base Information

Chemical Name:N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide
CAS No.:109553-34-6
Molecular Formula:C₂₀H₃₀F₂N₂O₅
Molecular Weight:416.465
Hs Code.:

Synonyms:N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide

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Technology Process of N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide

There total 1 articles about N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 104-94-9
4-methoxy-aniline

: 109553-33-5
Sodium; (3S,4S)-4-tert-butoxycarbonylamino-2,2-difluoro-3-hydroxy-6-methyl-heptanoate

: 109553-34-6
N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1021/jm00393a026

Reference yield: 92.0%

: 109553-34-6
N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide

: 109584-53-4
4(R)-<1(S)-<(tert-butyloxycarbonyl)amino>-3-methylbutyl>-3,3-difluoro-1-(methoxyphenyl)-2-azetidinone

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm00393a026

Reference yield:

: 109553-34-6
N-(4-methoxyphenyl)-4(S)-<(tert-butyloxycarbonyl)amino>-2,2-difluoro-3(S)-hydroxy-6-methylheptanamide

: 109553-35-7
sodium 4(S)-<(tert-butoxycarbonyl)amino>-2,2-difluoro-3(R)-<(4-methoxyphenyl)amino>-6-methylheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

2: 1M aq. NaOH / tetrahydrofuran / 20 h

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jm00393a026