4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine

Base Information

Chemical Name:4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine
CAS No.:237435-63-1
Molecular Formula:C₂₀H₂₃FN₄
Molecular Weight:338.428
Hs Code.:

Synonyms:4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine

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Chemical Property of 4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine

Chemical Property:

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Technology Process of 4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine

There total 5 articles about 4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 237435-61-9
4-((6S,2R)-2,6-dimethylpiperidyl)-6-chloro-2-methylpyrimidin-5-ylamine

: 237435-63-1
4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine

Guidance literature:

Reference yield:

: 13162-43-1
4,6-dichloro-2-methyl-5-nitropyrimidine

: 237435-63-1
4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; ethyl acetate

2: sodium hydroxide / concentrated aqueous HCl; diethyl ether; ethyl acetate

With sodium hydroxide; triethylamine; In tetrahydrofuran; concentrated aqueous HCl; diethyl ether; ethyl acetate;

Reference yield:

: 1194-22-5
2-methyl-4,6-dihydroxypyrimidine

: 237435-63-1
4-((6S,2R)-2,6-Dimethylpiperidyl)-6-[2-(4-fluoro phenyl)ethynyl]-2-methylpyrimidine-5-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; trifluoroacetic acid / water

2: trichlorophosphate / n-heptane; toluene

3: triethylamine / tetrahydrofuran; ethyl acetate

4: sodium hydroxide / concentrated aqueous HCl; diethyl ether; ethyl acetate

With sodium hydroxide; nitric acid; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; concentrated aqueous HCl; diethyl ether; n-heptane; water; ethyl acetate; toluene;