1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one

Base Information

Chemical Name:1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one
CAS No.:136320-93-9
Molecular Formula:C₂₈H₃₈O₆
Molecular Weight:470.606
Hs Code.:

Synonyms:1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one

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Chemical Property of 1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one

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Technology Process of 1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one

There total 6 articles about 1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: 136320-93-9
1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / DMAP, pyridine / 2 h

2: TsOH / 0.17 h

3: HC(OMe)3, TsOH

4: 94 percent / K₂CO₃ / methanol / 3 h / 60 °C

5: 87 percent / SO₃*pyridine, Et₃N / dimethylsulfoxide / 3 h

6: 2) MnO₂ / 1) THF, -40 to 0 degC, 1.5 h, 2) benzene, 4 h

With pyridine; dmap; manganese(IV) oxide; pyridine-SO₃ complex; potassium carbonate; toluene-4-sulfonic acid; triethylamine; trimethyl orthoformate; In methanol; dimethyl sulfoxide;
DOI:10.1016/0040-4039(91)80618-G

Reference yield:

: 136321-06-7
[(2S,3aS,5aR,9R,9aS,9bS)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-methanol

: 136320-93-9
1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / SO₃*pyridine, Et₃N / dimethylsulfoxide / 3 h

2: 2) MnO₂ / 1) THF, -40 to 0 degC, 1.5 h, 2) benzene, 4 h

With manganese(IV) oxide; pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide;
DOI:10.1016/0040-4039(91)80618-G

Reference yield:

: Benzoic acid (1S,2S,4aR,8R,8aS)-8-(4-methoxy-benzyloxy)-2,5,5,8a-tetramethyl-1,2-bis-(toluene-4-sulfonyloxy)-decahydro-naphthalen-1-ylmethyl ester

: 136320-93-9
1-[(2S,3aS,5aR,9R,9aS,9bR)-2-Methoxy-9-(4-methoxy-benzyloxy)-3a,6,6,9a-tetramethyl-octahydro-naphtho[1,2-d][1,3]dioxol-9b-yl]-but-2-yn-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: TsOH / 0.17 h

2: HC(OMe)3, TsOH

3: 94 percent / K₂CO₃ / methanol / 3 h / 60 °C

4: 87 percent / SO₃*pyridine, Et₃N / dimethylsulfoxide / 3 h

5: 2) MnO₂ / 1) THF, -40 to 0 degC, 1.5 h, 2) benzene, 4 h

With manganese(IV) oxide; pyridine-SO₃ complex; potassium carbonate; toluene-4-sulfonic acid; triethylamine; trimethyl orthoformate; In methanol; dimethyl sulfoxide;
DOI:10.1016/0040-4039(91)80618-G